Application of veno-venous extracorporeal membrane oxygenation in lymphoma patients with severe acute respiratory distress syndrome

Aim: To report the clinical courses of two patients, one with Hodgkin’s lymphoma (HL) and Non-Hodgkin’s (NHL), who developed severe refractory acute respiratory distress syndrome (ARDS) were treated veno-venous extracorporeal membrane oxygenation (VV ECMO). Case report: Both patients chemotherapy-associated febrile neutropenia followed by pneumonia ARDS, after which they transferred to intensive care unit. Their failure deteriorated despite endotracheal intubation protective mechanical ventilation, at point a decision for VV ECMO initiation was made. had complicated treatment ECMO-associated complications. The most important complications support in our HL patient cardiac arrest; right atrial laceration pericardial tamponade needed surgical treatment; leg ischemia required transfemoral amputation; thrombosis within oxygenator; several septic episodes hemodynamic instability; sided tension pneumothorax. Despite all difficulties, successfully weaned from ECMO. Unfortunately, he died prior hospital discharge as result sepsis multiple organ failure. significant ECMO-induced NHL bleeding incidents, notably diffuse oropharyngeal continuous bilateral pulmonary hemorrhage; superimposed bacterial pneumonia; extensive pneumomediastinum subcutaneous emphysema. therapeutic efforts, during because decompensation. Conclusions: hematologic malignancies (HMs) undergoing have poor outcomes, high rates Further studies focusing on selection issues concerning prevention, diagnosis are needed.